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Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats
Joint Authors
Garza-Ocañas, Lourdes
Alcaraz-Contreras, Yolanda
Ramírez-Gómez, Xóchitl Sofía
Carcaño-Díaz, Katya
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The effectiveness of glycine in treating experimental lead intoxication was examined in rats.
Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally) once daily for 28 days.
The effect of these treatments on parameters indicative of oxidative stress (glutathione and malondialdehyde levels), the activity of blood δ-aminolevulinic acid dehydratase, and lead concentration in blood, liver, kidney, brain, and bone were investigated.
Liver samples were observed for histopathological changes.
Glycine was found to be effective in (1) increasing glutathione levels; (2) reducing malondialdehyde levels; (3) decreasing lead levels in bone with the highest dose.
However, glycine had no effect on lead mobilization when 100 and 500 mg/kg glycine were administered.
In microscopic examination, glycine showed a protective effect against lead intoxication.
American Psychological Association (APA)
Alcaraz-Contreras, Yolanda& Garza-Ocañas, Lourdes& Carcaño-Díaz, Katya& Ramírez-Gómez, Xóchitl Sofía. 2011. Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-471678
Modern Language Association (MLA)
Alcaraz-Contreras, Yolanda…[et al.]. Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats. Journal of Toxicology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-471678
American Medical Association (AMA)
Alcaraz-Contreras, Yolanda& Garza-Ocañas, Lourdes& Carcaño-Díaz, Katya& Ramírez-Gómez, Xóchitl Sofía. Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-471678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471678