Homologue Pairing in Flies and Mammals : Gene Regulation When Two Are Involved
Joint Authors
Apte, Manasi S.
Meller, Victoria H.
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chromosome pairing is usually discussed in the context of meiosis.
Association of homologues in germ cells enables chromosome segregation and is necessary for fertility.
A few organisms, such as flies, also pair their entire genomes in somatic cells.
Most others, including mammals, display little homologue pairing outside of the germline.
Experimental evidence from both flies and mammals suggests that communication between homologues contributes to normal genome regulation.
This paper will contrast the role of pairing in transmitting information between homologues in flies and mammals.
In mammals, somatic homologue pairing is tightly regulated, occurring at specific loci and in a developmentally regulated fashion.
Inappropriate pairing, or loss of normal pairing, is associated with gene misregulation in some disease states.
While homologue pairing in flies is capable of influencing gene expression, the significance of this for normal expression remains unknown.
The sex chromosomes pose a particularly interesting situation, as females are able to pair X chromosomes, but males cannot.
The contribution of homologue pairing to the biology of the X chromosome will also be discussed.
American Psychological Association (APA)
Apte, Manasi S.& Meller, Victoria H.. 2011. Homologue Pairing in Flies and Mammals : Gene Regulation When Two Are Involved. Genetics Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471684
Modern Language Association (MLA)
Apte, Manasi S.& Meller, Victoria H.. Homologue Pairing in Flies and Mammals : Gene Regulation When Two Are Involved. Genetics Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-471684
American Medical Association (AMA)
Apte, Manasi S.& Meller, Victoria H.. Homologue Pairing in Flies and Mammals : Gene Regulation When Two Are Involved. Genetics Research International. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471684