Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1 : A Systematic Review
Joint Authors
Treglia, Giorgio
Giordano, Alessandro
Salsano, Marco
Vita, Maria Letizia
Bertagna, Francesco
Maggi, Fabio
Taralli, Silvia
Novellis, Pierluigi
Muoio, Barbara
Source
Radiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To systematically review the role of positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG) in patients with neurofibromatosis type 1 (NF1).
Methods.
A comprehensive literature search of published studies regarding FDG-PET and PET/CT in patients with NF1 was performed.
No beginning date limit and language restriction were used; the search was updated until December 2011.
Only those studies or subsets in studies including whole-body FDG-PET or PET/CT scans performed in patients with NF1 were included.
Results.
We identified 12 studies including 352 NF1 patients.
Qualitative evaluation was performed in about half of the studies and semiquantitative analysis, mainly based on different values of SUV cutoff, in the others.
Most of the studies evaluated the role of FDG-PET for differentiating benign from malignant peripheral nerve sheath tumors (MPNSTs).
Malignant lesions were detected with a sensitivity ranging between 100% and 89%, but with lower specificity, ranging between 100% and 72%.
Moreover, FDG-PET seems to be an important imaging modality for predicting the progression to MPNST and the outcome in patients with MPNST.
Two studies evaluated the role of FDG-PET in pediatric patients with NF1.
Conclusions.
FDG-PET and PET/CT are useful methods to identify malignant change in neurogenic tumors in NF1 and to discriminate malignant from benign neurogenic lesions.
American Psychological Association (APA)
Treglia, Giorgio& Taralli, Silvia& Bertagna, Francesco& Salsano, Marco& Muoio, Barbara& Novellis, Pierluigi…[et al.]. 2012. Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1 : A Systematic Review. Radiology Research and Practice،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471724
Modern Language Association (MLA)
Treglia, Giorgio…[et al.]. Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1 : A Systematic Review. Radiology Research and Practice No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-471724
American Medical Association (AMA)
Treglia, Giorgio& Taralli, Silvia& Bertagna, Francesco& Salsano, Marco& Muoio, Barbara& Novellis, Pierluigi…[et al.]. Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1 : A Systematic Review. Radiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471724