Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model
Joint Authors
Moskaluk, Christopher
Gatesman, Jeremy
Gaidhane, Monica R.
Ellen, Kristi
Habib, Nagy A.
Foley, Patricia
Kahaleh, Michel
Smith, Ioana
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Backgrounds.
Limited effective palliative treatments exist for pancreatic cancer which includes surgery or chemotherapy.
Radiofrequency ablation (RFA) uses high frequency alternating current to ablate diseased tissue and has been used to treat various tumors.
In this study, we evaluated a prototype probe adjusted to the EUS-needle to perform EUS-RFA to permit coagulative necrosis in the pancreas.
Methods.
Five Yucatan pigs underwent EUS-guided radiofrequency ablation of the head of their pancreas.
Using an EUS-needle, RFA was applied with 6 mm and then 10 mm of the probe exposed at specific wattage for preset durations.
Results.
Only one pig showed moderate levels of pancreatitis (20% proximal pancreatitis).
The other animals showed much lower areas of tissue damage.
In 3 of the 5 pigs, the proximal pancreas showed greater levels of tissue injury than the distal pancreas, consistent with the proximity of the tissue to the procedure site.
In 1 pig, both proximal and distal pancreas showed minimal pancreatitis (1%).
There was minimal evidence of fat necrosis in intra-pancreatic and/or extra-pancreatic adipose tissue.
Conclusion.
EUS-guided RFA of the pancreatic head with the monopolar probe through a 19-gauge needle was well tolerated in 5 Yucatan pigs and with minimal amount of pancreatitis.
American Psychological Association (APA)
Gaidhane, Monica R.& Smith, Ioana& Ellen, Kristi& Gatesman, Jeremy& Habib, Nagy A.& Foley, Patricia…[et al.]. 2012. Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471749
Modern Language Association (MLA)
Gaidhane, Monica R.…[et al.]. Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471749
American Medical Association (AMA)
Gaidhane, Monica R.& Smith, Ioana& Ellen, Kristi& Gatesman, Jeremy& Habib, Nagy A.& Foley, Patricia…[et al.]. Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471749