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Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice
Joint Authors
Younes, Areej K.
Volk, Kenneth A.
Hermann, Gregory M.
Kummet, Gary J.
Miller, Alise K.
Roghair, Robert D.
Ni, Charles
Haskell, Sarah E.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Selective serotonin reuptake inhibitor (SSRI) therapy complicates up to 10% of pregnancies.
During therapy, SSRIs exert pleiotropic antidepressant, anorexigenic, and neurotrophic effects.
Intrauterine SSRI exposure has been modeled by neonatal administration to developmentally immature rodents, and it has paradoxically elicited features of adult depression.
We hypothesized neonatal SSRI exposure likewise programs a rebound hypermetabolic state in adult mice.
Methods.
C57BL/6 pups were randomized to saline or sertraline (5 mg/kg/d) from P1–P14.
Because estrogen increases tryptophan hydroxylase 2 (TPH2) expression, a subset of female mice underwent sham surgery or bilateral ovariectomy (OVX).
Metabolic rate was determined by indirect calorimetry.
Results.
In both male and female mice, neonatal SSRI exposure increased adult caloric intake and metabolic rate.
SSRI-exposed female mice had significantly decreased adult weight with a relative increase in brain weight and melatonin excretion, independent of ovarian status.
Cerebral cortex TPH2 expression was increased in SSRI-exposed male mice but decreased in OVX SSRI-exposed female mice.
Conclusions.
SSRI exposure during a critical neurodevelopmental window increases adult caloric intake and metabolic rate.
Ovarian status modulated central TPH2 expression, but not adult energy balance, suggesting programmed neural connectivity or enhanced melatonin production may play a more important role in the post-SSRI hypermetabolic syndrome.
American Psychological Association (APA)
Kummet, Gary J.& Haskell, Sarah E.& Hermann, Gregory M.& Ni, Charles& Volk, Kenneth A.& Younes, Areej K.…[et al.]. 2012. Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471759
Modern Language Association (MLA)
Kummet, Gary J.…[et al.]. Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-471759
American Medical Association (AMA)
Kummet, Gary J.& Haskell, Sarah E.& Hermann, Gregory M.& Ni, Charles& Volk, Kenneth A.& Younes, Areej K.…[et al.]. Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471759