EGF and TGF-β1 Effects on Thyroid Function
Joint Authors
D'Inzeo, Sonia
Tarantelli, Chiara
Nardi, Francesco
Donini, Caterina Francesca
Nicolussi, Arianna
Di Marcantonio, Maria Carmela
Coppa, Anna
Mincione, Gabriella
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Normal epithelial thyroid cells in culture are inhibited by TGF-β1.
Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect.
Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as shown in transformed rat thyroid cell lines and in human thyroid tumors, or to alterations of other genes controlling TGF-β signal transduction pathway.
However, in thyroid neoplasia, a complex pattern of alterations occurring during transformation and progression has been identified.
Functionally, TGF-β1 acts as a tumor suppressor in the early stage of transformation or as a tumor promoter in advanced cancer.
This peculiar pleiotropic behaviour of TGF-β may result from cross-talk with signalling pathways mediated by other growth factors, among which EGF-like ligands play an important role.
This paper reports evidences on TGF-β1 and EGF systems in thyroid tumors and on the cross-talk between these growth factors in thyroid cancer.
American Psychological Association (APA)
Mincione, Gabriella& Di Marcantonio, Maria Carmela& Tarantelli, Chiara& D'Inzeo, Sonia& Nicolussi, Arianna& Nardi, Francesco…[et al.]. 2011. EGF and TGF-β1 Effects on Thyroid Function. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-471770
Modern Language Association (MLA)
Mincione, Gabriella…[et al.]. EGF and TGF-β1 Effects on Thyroid Function. Journal of Thyroid Research No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-471770
American Medical Association (AMA)
Mincione, Gabriella& Di Marcantonio, Maria Carmela& Tarantelli, Chiara& D'Inzeo, Sonia& Nicolussi, Arianna& Nardi, Francesco…[et al.]. EGF and TGF-β1 Effects on Thyroid Function. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-471770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471770