Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban
Joint Authors
Bea, Florian
Zhou, Qianxing
Isermann, Berend
Blessing, Erwin
Katus, Hugo A.
Shahzad, Khurrum
Wang, Hongjie
Preusch, Michael
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
Thrombin not only plays a central role in thrombus formation and platelet activation, but also in induction of inflammatory processes.
Activated factor X (FXa) is traditionally known as an important player in the coagulation cascade responsible for thrombin generation.
We assessed the hypothesis that rivaroxaban, a direct FXa inhibitor, attenuates plaque progression and promotes stability of advanced atherosclerotic lesions in an in vivo model.
Methods and Results.
Rivaroxaban (1 or 5 mg/kg body weight/day) or standard chow diet was administered for 26 weeks to apolipoprotein E-deficient mice (n=20 per group) with already established atherosclerotic lesions.
There was a nonsignificant reduction of lesion progression in the high-concentration group, compared to control mice.
FXa inhibition with 5 mg Rivaroxaban/kg/day resulted in increased thickness of the protective fibrous caps (12.3±3.8 μm versus 10.1±2.7 μm; P<.05), as well as in fewer medial erosions and fewer lateral xanthomas, indicating plaque stabilizing properties.
Real time-PCR from thoracic aortas revealed that rivaroxaban (5 mg/kg/day) treatment reduced mRNA expression of inflammatory mediators, such of IL-6, TNF-α, MCP-1, and Egr-1 (P<.05).
Conclusions.
Chronic administration of rivaroxaban does not affect lesion progression but downregulates expression of inflammatory mediators and promotes lesion stability in apolipoprotein E-deficient mice.
American Psychological Association (APA)
Zhou, Qianxing& Bea, Florian& Preusch, Michael& Wang, Hongjie& Isermann, Berend& Shahzad, Khurrum…[et al.]. 2011. Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471813
Modern Language Association (MLA)
Zhou, Qianxing…[et al.]. Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban. Mediators of Inflammation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-471813
American Medical Association (AMA)
Zhou, Qianxing& Bea, Florian& Preusch, Michael& Wang, Hongjie& Isermann, Berend& Shahzad, Khurrum…[et al.]. Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471813