Nonequilibrium Thermodynamics of Cell Signaling
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Signal transduction inside and across the cells, also called cellular signaling, is key to most biological functions and is ultimately related with both life and death of the organisms.
The processes giving rise to the propagation of biosignals are complex and extremely cooperative and occur in a far-from thermodynamic equilibrium regime.
They are also driven by activation kinetics strongly dependent on local energetics.
For these reasons, a nonequilibrium thermodynamical description, taking into account not just the activation of second messengers, but also transport processes and dissipation is desirable.
Here we present a proposal for such a formalism, that considers cells as small thermodynamical systems and incorporates the role of fluctuations as intrinsic to the dynamics in a spirit guided by mesoscopic nonequilibrium thermodynamics.
We present also a minimal model for cellular signaling that includes contributions from activation, transport, and intrinsic fluctuations.
We finally illustrate its feasibility by considering the case of FAS signaling which is a vital signal transduction pathway that determines either cell survival or death by apoptosis.
American Psychological Association (APA)
Hernández-Lemus, Enrique. 2012. Nonequilibrium Thermodynamics of Cell Signaling. Journal of Thermodynamics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-471824
Modern Language Association (MLA)
Hernández-Lemus, Enrique. Nonequilibrium Thermodynamics of Cell Signaling. Journal of Thermodynamics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-471824
American Medical Association (AMA)
Hernández-Lemus, Enrique. Nonequilibrium Thermodynamics of Cell Signaling. Journal of Thermodynamics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-471824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471824