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Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats
Joint Authors
Gomes, José Carlos
Costa de Oliveira, Déborah Mara
Di Stasi, Luiz Claudio
Luchini, Ana Carolina
Pellizzon, Cláudia Helena
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid.
Colitis induction increased the histamine concentration in the colon, which peaked on day 26.
The number of mast cells, probably immature, was ten times higher on day 8.
Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli.
Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells.
In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses.
American Psychological Association (APA)
Luchini, Ana Carolina& Costa de Oliveira, Déborah Mara& Pellizzon, Cláudia Helena& Di Stasi, Luiz Claudio& Gomes, José Carlos. 2009. Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-471849
Modern Language Association (MLA)
Luchini, Ana Carolina…[et al.]. Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-471849
American Medical Association (AMA)
Luchini, Ana Carolina& Costa de Oliveira, Déborah Mara& Pellizzon, Cláudia Helena& Di Stasi, Luiz Claudio& Gomes, José Carlos. Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-471849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471849