XMRV Discovery and Prostate Cancer-Related Research
Joint Authors
Das Gupta, Jaydip
Silverman, Robert H.
Kang, David E.
Lee, Michael C.
Klein, Eric A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L.
Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals.
The principal confounding factors are the near ubiquitous presence of mouse-derived reagents, antibodies and cells, and often XMRV itself, in laboratories.
XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines.
XMRV also traffics to prostate in a nonhuman primate model of infection.
Here, we will review the discovery of XMRV and then focus on prostate cancer-related research involving this intriguing virus.
American Psychological Association (APA)
Kang, David E.& Lee, Michael C.& Das Gupta, Jaydip& Klein, Eric A.& Silverman, Robert H.. 2011. XMRV Discovery and Prostate Cancer-Related Research. Advances in Virology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-471897
Modern Language Association (MLA)
Kang, David E.…[et al.]. XMRV Discovery and Prostate Cancer-Related Research. Advances in Virology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-471897
American Medical Association (AMA)
Kang, David E.& Lee, Michael C.& Das Gupta, Jaydip& Klein, Eric A.& Silverman, Robert H.. XMRV Discovery and Prostate Cancer-Related Research. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-471897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471897