Antiulcerogenic Potential Activity of Free and Nanoencapsulated Passiflora serratodigitata L. Extracts
Joint Authors
Bou-Chacra, Nádia
Löbenberg, Raimar
Strasser, Marc
Bacchi, Elfriede M.
Noriega, Peky
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This paper provides evidence that the leaves and stem of Passiflora serratodigitata L.
dry crude extract (DCE), ethylacetate fraction (EAF), and residual water fraction show potential antiulcerogenic activity.
Interestingly, the polymeric nanocapsule loaded with EAF had 10-fold more activity than the free EAF.
Furthermore, the polymer nanoparticles provided homogeneous colloidal drug delivery systems and allowed overcoming challenges such as poor aqueous solubility as well as the physical-chemical instability of the organic extract, which presented 90% (w/w) of the flavonoid content.
The entrapment efficiency of the total flavonoid was 90.6 ± 2.5% (w/v) for the DCE and 79.9 ± 2.7% (w/v) for the EAF.
This study shows that nanoencapsulation improves both the physicochemical properties and the efficacy of the herbal formulations.
Therefore, free and encapsulated extracts have the potential to be suitable drug design candidates for the therapeutic management of ulcer.
American Psychological Association (APA)
Strasser, Marc& Noriega, Peky& Löbenberg, Raimar& Bou-Chacra, Nádia& Bacchi, Elfriede M.. 2014. Antiulcerogenic Potential Activity of Free and Nanoencapsulated Passiflora serratodigitata L. Extracts. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471922
Modern Language Association (MLA)
Strasser, Marc…[et al.]. Antiulcerogenic Potential Activity of Free and Nanoencapsulated Passiflora serratodigitata L. Extracts. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471922
American Medical Association (AMA)
Strasser, Marc& Noriega, Peky& Löbenberg, Raimar& Bou-Chacra, Nádia& Bacchi, Elfriede M.. Antiulcerogenic Potential Activity of Free and Nanoencapsulated Passiflora serratodigitata L. Extracts. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471922