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Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats
Joint Authors
Mubarak, Mohammed
Ashour, Abdelkader E.
Alkhalidi, Hisham
Korashy, Hesham M.
Sayed-Ahmed, Mohammed M.
Abd-Allah, Adel R.
Maayah, Zaid H.
Alhaider, Abdulqader
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects.
Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity.
However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported.
Our results, in a rat model of DOX-induced cardiotoxicity, show that DOX treatment significantly increased serum levels of LDH and CK-MB, indicators of cardiac injury, and induced expression of hypertrophic gene markers.
DOX also caused marked decreases in the cardiac levels of glutathione, CoA-SH and ATP, and mRNA expression of catalase and NQO-1.
These biochemical changes were associated with myocardial histopathological and ultrastructural deteriorations, as observed by light and electron microscopy, respectively.
Cotreatment with MET (500 mg/kg) eliminated all DOX-induced biochemical, histopathological, and ultrastructural changes.
These findings demonstrate that MET successfully prevents DOX-induced cardiotoxicity in vivo by inhibiting DOX-induced oxidative stress, energy starvation, and depletion of intramitochondrial CoA-SH.
American Psychological Association (APA)
Ashour, Abdelkader E.& Sayed-Ahmed, Mohammed M.& Abd-Allah, Adel R.& Korashy, Hesham M.& Maayah, Zaid H.& Alkhalidi, Hisham…[et al.]. 2012. Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-471931
Modern Language Association (MLA)
Ashour, Abdelkader E.…[et al.]. Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-471931
American Medical Association (AMA)
Ashour, Abdelkader E.& Sayed-Ahmed, Mohammed M.& Abd-Allah, Adel R.& Korashy, Hesham M.& Maayah, Zaid H.& Alkhalidi, Hisham…[et al.]. Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-471931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471931