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Optimization Manufacture of Virus- and Tumor-Specific T Cells
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Although ex vivo expanded T cells are currently widely used in pre-clinical and clinical trials, the complexity of manufacture remains a major impediment for broader application.
In this review we discuss current protocols for the ex vivo expansion of virus- and tumor-specific T cells and describe our experience in manufacture optimization using a gas-permeable static culture flask (G-Rex).
This innovative device has revolutionized the manufacture process by allowing us to increase cell yields while decreasing the frequency of cell manipulation and in vitro culture time.
It is now being used in good manufacturing practice (GMP) facilities for clinical cell production in our institution as well as many others in the US and worldwide.
American Psychological Association (APA)
Lapteva, Natalia& Vera, Juan F.. 2011. Optimization Manufacture of Virus- and Tumor-Specific T Cells. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471940
Modern Language Association (MLA)
Lapteva, Natalia& Vera, Juan F.. Optimization Manufacture of Virus- and Tumor-Specific T Cells. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-471940
American Medical Association (AMA)
Lapteva, Natalia& Vera, Juan F.. Optimization Manufacture of Virus- and Tumor-Specific T Cells. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471940