The Stability of the Induced Epigenetic Programs

Author

Barrero, Maria J.

Source

Comparative and Functional Genomics

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-06-03

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

For many years scientists have been attracted to the possibility of changing cell identity.

In the last decades seminal discoveries have shown that it is possible to reprogram somatic cells into pluripotent cells and even to transdifferentiate one cell type into another.

In view of the potential applications that generating specific cell types in the laboratory can offer for cell-based therapies, the next important questions relate to the quality of the induced cell types.

Importantly, epigenetic aberrations in reprogrammed cells have been correlated with defects in differentiation.

Therefore, a look at the epigenome and understanding how different regulators can shape it appear fundamental to anticipate potential therapeutic pitfalls.

This paper covers these epigenetic aspects in stem cells, differentiation, and reprogramming and discusses their importance for the safety of in vitro engineered cell types.

American Psychological Association (APA)

Barrero, Maria J.. 2012. The Stability of the Induced Epigenetic Programs. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471942

Modern Language Association (MLA)

Barrero, Maria J.. The Stability of the Induced Epigenetic Programs. Comparative and Functional Genomics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-471942

American Medical Association (AMA)

Barrero, Maria J.. The Stability of the Induced Epigenetic Programs. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471942

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-471942