The Stability of the Induced Epigenetic Programs
Author
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
For many years scientists have been attracted to the possibility of changing cell identity.
In the last decades seminal discoveries have shown that it is possible to reprogram somatic cells into pluripotent cells and even to transdifferentiate one cell type into another.
In view of the potential applications that generating specific cell types in the laboratory can offer for cell-based therapies, the next important questions relate to the quality of the induced cell types.
Importantly, epigenetic aberrations in reprogrammed cells have been correlated with defects in differentiation.
Therefore, a look at the epigenome and understanding how different regulators can shape it appear fundamental to anticipate potential therapeutic pitfalls.
This paper covers these epigenetic aspects in stem cells, differentiation, and reprogramming and discusses their importance for the safety of in vitro engineered cell types.
American Psychological Association (APA)
Barrero, Maria J.. 2012. The Stability of the Induced Epigenetic Programs. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471942
Modern Language Association (MLA)
Barrero, Maria J.. The Stability of the Induced Epigenetic Programs. Comparative and Functional Genomics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-471942
American Medical Association (AMA)
Barrero, Maria J.. The Stability of the Induced Epigenetic Programs. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471942