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The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors
Joint Authors
Martinez, Teresa
Garcia-Buela, Jesús
Vidal, Ovidio
Cordido, Fernando
Sangiao-Alvarellos, Susana
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance.
Premenopausal obese women, aged 35–52 years, were studied.
GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured.
Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was ≤3 μg/L.
Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient.
Peak GH secretion after stimulation was inversely associated with fasting insulin (R=−0.650, P=.012), HOMA-IR (R=−0.846, P=.001), total cholesterol (R=−0.532, P=.034), and LDL cholesterol (R=−0.692, P=.006) and positively associated with HDL cholesterol (R=0.561, P=.037).
These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.
American Psychological Association (APA)
Cordido, Fernando& Garcia-Buela, Jesús& Sangiao-Alvarellos, Susana& Martinez, Teresa& Vidal, Ovidio. 2010. The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-471946
Modern Language Association (MLA)
Cordido, Fernando…[et al.]. The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors. Mediators of Inflammation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-471946
American Medical Association (AMA)
Cordido, Fernando& Garcia-Buela, Jesús& Sangiao-Alvarellos, Susana& Martinez, Teresa& Vidal, Ovidio. The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-471946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471946