![](/images/graphics-bg.png)
Renal Function in Relation to Cardiac 123I-MIBG Scintigraphy in Patients with Chronic Heart Failure
Joint Authors
van Eck-Smit, Berthe L. F.
Verschure, Derk O.
Verberne, Hein J.
Somsen, G. Aernout
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to explore if estimates of renal function could explain variability of 123I-metaiodobenzylguanidine (123I-MIBG) assessed myocardial sympathetic activity.
Furthermore estimates of renal function were compared to 123I-MIBG as predictors of cardiac death in chronic heart failure (CHF).
Semi-quantitative parameters of 123I-MIBG myocardial uptake and washout were calculated using early heart/mediastinum ratio (H/M), late H/M and washout.
Renal function was calculated as estimated Creatinine Clearance (e-CC) and as estimated Glomerular Filtration Rate (e-GFR).
Thirty-nine patients with CHF (24 males; age: 64.4±10.5 years; NYHA II/III/IV: 17/20/2; LVEF: 24.0±11.5%) were studied.
Variability in any of the semi-quantitative 123I-MIBG myocardial parameters could not be explained by e-CC or e-GFR.
During follow-up (60±37 months) there were 6 cardiac deaths.
Cox proportional hazard regression analysis showed that late H/M was the only independent predictor for cardiac death (Chi-square 3.2, regression coefficient: −4.095; standard error: 2.063; hazard ratio: 0.17 [95% CI: 0.000–0.950]).
Addition of estimates of renal function did not significantly change the Chi-square of the model.
Semi-quantitative 123I-MIBG myocardial parameters are independent of estimates of renal function.
In addition, cardiac sympathetic innervation assessed by 123I-MIBG scintigraphy seems to be superior to renal function in the prediction of cardiac death in CHF patients.
American Psychological Association (APA)
Verschure, Derk O.& Somsen, G. Aernout& van Eck-Smit, Berthe L. F.& Verberne, Hein J.. 2012. Renal Function in Relation to Cardiac 123I-MIBG Scintigraphy in Patients with Chronic Heart Failure. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471963
Modern Language Association (MLA)
Verschure, Derk O.…[et al.]. Renal Function in Relation to Cardiac 123I-MIBG Scintigraphy in Patients with Chronic Heart Failure. International Journal of Molecular Imaging No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-471963
American Medical Association (AMA)
Verschure, Derk O.& Somsen, G. Aernout& van Eck-Smit, Berthe L. F.& Verberne, Hein J.. Renal Function in Relation to Cardiac 123I-MIBG Scintigraphy in Patients with Chronic Heart Failure. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471963