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Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology : Implications for Brain Homeostasis
Joint Authors
Li, Wei
Aw, Tak Yee
Circu, Magdalena L.
Busu, Carmina
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The integrity of the vascular endothelium of the blood-brain barrier (BBB) is central to cerebrovascular homeostasis.
Given the function of the BBB as a physical and metabolic barrier that buffers the systemic environment, oxidative damage to the endothelial monolayer will have significant deleterious impact on the metabolic, immunological, and neurological functions of the brain.
Glutathione (GSH) is a ubiquitous major thiol within mammalian cells that plays important roles in antioxidant defense, oxidation-reduction reactions in metabolic pathways, and redox signaling.
The existence of distinct GSH pools within the subcellular organelles supports an elegant mode for independent redox regulation of metabolic processes, including those that control cell fate.
GSH-dependent homeostatic control of neurovascular function is relatively unexplored.
Significantly, GSH regulation of two aspects of endothelial function is paramount to barrier preservation, namely, GSH protection against oxidative endothelial cell injury and GSH control of postdamage cell proliferation in endothelial repair and/or wound healing.
This paper highlights our current insights and hypotheses into the role of GSH in cerebral microvascular biology and pathobiology with special focus on endothelial GSH and vascular integrity, oxidative disruption of endothelial barrier function, GSH regulation of endothelial cell proliferation, and the pathological implications of GSH disruption in oxidative stress-associated neurovascular disorders, such as diabetes and stroke.
American Psychological Association (APA)
Li, Wei& Busu, Carmina& Circu, Magdalena L.& Aw, Tak Yee. 2012. Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology : Implications for Brain Homeostasis. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-471977
Modern Language Association (MLA)
Li, Wei…[et al.]. Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology : Implications for Brain Homeostasis. International Journal of Cell Biology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-471977
American Medical Association (AMA)
Li, Wei& Busu, Carmina& Circu, Magdalena L.& Aw, Tak Yee. Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology : Implications for Brain Homeostasis. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-471977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471977