Glycemic Profiles of Healthy Individuals with Low Fasting Plasma Glucose and HbA1c

Abstract EN

Scant data exists on glucose profile variability in healthy individuals.

Twenty-nine healthy subjects without diabetes (86% male; mean age, 38 years) were measured by a CGM system and under real-life conditions.

The median percentage of time spent on the blood glucose >7.8 mmol/L for 24 hrs was greater than 10% in both NFG and IFG groups.

When subjects were divided into either NFG group (i.e., FPG levels of <5.6 mmol/L; n=22) or IFG group (FPG levels of 5.6–6.9 mmol/L; n=7), all CGM indicators investigated but GRADE scores, including glucose variability measures, monitoring excursions, hyperglycemia, hypoglycemia, and 24-hour AUC, did not differ significantly between the two groups.

GRADE score and its euglycemia% were significantly different between the two groups.

Among various CGM indicators, GRADE score may be a sensitive indicator to discriminate glucose profiles between subjects with NFG and those with IFG.