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The Use of Mixed Models for the Analysis of Mediated Data with Time-Dependent Predictors
Joint Authors
Blood, Emily A.
Cheng, Debbie M.
Source
Journal of Environmental and Public Health
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Linear mixed models (LMMs) are frequently used to analyze longitudinal data.
Although these models can be used to evaluate mediation, they do not directly model causal pathways.
Structural equation models (SEMs) are an alternative technique that allows explicit modeling of mediation.
The goal of this paper is to evaluate the performance of LMMs relative to SEMs in the analysis of mediated longitudinal data with time-dependent predictors and mediators.
We simulated mediated longitudinal data from an SEM and specified delayed effects of the predictor.
A variety of model specifications were assessed, and the LMMs and SEMs were evaluated with respect to bias, coverage probability, power, and Type I error.
Models evaluated in the simulation were also applied to data from an observational cohort of HIV-infected individuals.
We found that when carefully constructed, the LMM adequately models mediated exposure effects that change over time in the presence of mediation, even when the data arise from an SEM.
American Psychological Association (APA)
Blood, Emily A.& Cheng, Debbie M.. 2011. The Use of Mixed Models for the Analysis of Mediated Data with Time-Dependent Predictors. Journal of Environmental and Public Health،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-471988
Modern Language Association (MLA)
Blood, Emily A.& Cheng, Debbie M.. The Use of Mixed Models for the Analysis of Mediated Data with Time-Dependent Predictors. Journal of Environmental and Public Health No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-471988
American Medical Association (AMA)
Blood, Emily A.& Cheng, Debbie M.. The Use of Mixed Models for the Analysis of Mediated Data with Time-Dependent Predictors. Journal of Environmental and Public Health. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-471988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471988