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The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation
Joint Authors
Schultz, Marcus J.
Hemmes, Sabrine N. T.
Roelofs, Joris J. T. H.
Bos, Lieuwe D. J.
Hegeman, Maria A.
van der Sluijs, Koenraad F.
Juffermans, Nicole P.
Vroom, Margreeth B.
Jongsma, Geartsje
Kuipers, Maria T.
Source
Critical Care Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Mechanical ventilation (MV) has the potential to initiate ventilator-induced lung injury (VILI).
The pathogenesis of VILI has been primarily studied in animal models using more or less injurious ventilator settings.
However, we speculate that duration of MV also influences severity and character of VILI.
Methods.
Sixty-four healthy C57Bl/6 mice were mechanically ventilated for 5 or 12 hours, using lower tidal volumes with positive end-expiratory pressure (PEEP) or higher tidal volumes without PEEP.
Fifteen nonventilated mice served as controls.
Results.
All animals remained hemodynamically stable and survived MV protocols.
In both MV groups, PaO2 to FiO2 ratios were lower and alveolar cell counts were higher after 12 hours of MV compared to 5 hours.
Alveolar-capillary permeability was increased after 12 hours compared to 5 hours, although differences did not reach statistical significance.
Lung levels of inflammatory mediators did not further increase over time.
Only in mice ventilated with increased strain, lung compliance declined and wet to dry ratio increased after 12 hours of MV compared to 5 hours.
Conclusions.
Deleterious effects of MV are partly dependent on its duration.
Even lower tidal volumes with PEEP may initiate aspects of VILI after 12 hours of MV.
American Psychological Association (APA)
Hegeman, Maria A.& Hemmes, Sabrine N. T.& Kuipers, Maria T.& Bos, Lieuwe D. J.& Jongsma, Geartsje& Roelofs, Joris J. T. H.…[et al.]. 2013. The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation. Critical Care Research and Practice،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-472009
Modern Language Association (MLA)
Hegeman, Maria A.…[et al.]. The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation. Critical Care Research and Practice No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-472009
American Medical Association (AMA)
Hegeman, Maria A.& Hemmes, Sabrine N. T.& Kuipers, Maria T.& Bos, Lieuwe D. J.& Jongsma, Geartsje& Roelofs, Joris J. T. H.…[et al.]. The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation. Critical Care Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-472009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472009