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The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas
Joint Authors
Argyriou, Pinelopi
Papageorgiou, Sotirios G.
Economopoulou, Panagiota
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Despite the fact that the majority of lymphomas initially respond to treatment, many patients relapse and die from disease that is refractory to current regimens.
The need for new treatment strategies in lymphomas has led to the investigation and evaluation of novel agents that target cellular pathways.
The mammalian target of rapamycin (mTOR) is a representative pathway that may be implicated in lymphomagenesis.
Rapamycin and especially its derivatives (temsirolimus, everolimus, and deforolimus) represent the first described mTOR inhibitors.
These agents have shown promising results in the treatment of lymphoid malignancies.
On the other hand, new ATP-competitive mTOR inhibitors that provoke a broader inhibition of mTOR activity are in early stages of clinical development.
The purpose of this paper is to summarize the existing knowledge about mTOR inhibitors and their use in the treatment of B-cell lymphomas.
Relevant issues regarding mTOR biology in general as well as in B-cell lymphoid neoplasms are also discussed in short.
American Psychological Association (APA)
Argyriou, Pinelopi& Economopoulou, Panagiota& Papageorgiou, Sotirios G.. 2011. The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas. Advances in Hematology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-472020
Modern Language Association (MLA)
Argyriou, Pinelopi…[et al.]. The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas. Advances in Hematology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-472020
American Medical Association (AMA)
Argyriou, Pinelopi& Economopoulou, Panagiota& Papageorgiou, Sotirios G.. The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas. Advances in Hematology. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-472020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472020