![](/images/graphics-bg.png)
Severity of Hepatitis C Virus (Genotype-3) Infection Positively Correlates with Circulating MicroRNA-122 in Patients Sera
Joint Authors
Ghosh, Sujata
Chakraborti, Anuradha
Chawla, Yogesh Kumar
Kumar, Subodh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Hepatitis C virus (genotype-3) causes acute and chronic hepatitis infection predomination in India.
The infectious phase of the virus requires various host factors for its survival and subsequent viral particle production.
Small RNA molecules like microRNA-122 (miR-122) are one such factor mostly present in the liver and play a supportive role in viral replication.
Objective.
In this study, diagnostic potential of miR-122 is evaluated in the sera of chronic hepatitis C patients.
Methods.
miRNAs were isolated from the sera samples of patients as well as controls and miR-122 expression was quantified by real-time PCR.
Results.
A significant augmentation was observed in the level of circulating miR-122 (median level, 0.66 versus 0.29, P=0.001) in patients compared to controls with ROC value of 0.929±0.034 (P<0.001).
Interestingly, miR-122 level also depicted a significant positive correlation with serum ALT (r=0.53), AST (r=0.44), and viral load (r=0.52).
Conclusion.
The study thus unveiled the role of miR-122 as a plausible diagnostic biomarker during HCV genotype-3 infection in India.
American Psychological Association (APA)
Kumar, Subodh& Chawla, Yogesh Kumar& Ghosh, Sujata& Chakraborti, Anuradha. 2014. Severity of Hepatitis C Virus (Genotype-3) Infection Positively Correlates with Circulating MicroRNA-122 in Patients Sera. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-472031
Modern Language Association (MLA)
Kumar, Subodh…[et al.]. Severity of Hepatitis C Virus (Genotype-3) Infection Positively Correlates with Circulating MicroRNA-122 in Patients Sera. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-472031
American Medical Association (AMA)
Kumar, Subodh& Chawla, Yogesh Kumar& Ghosh, Sujata& Chakraborti, Anuradha. Severity of Hepatitis C Virus (Genotype-3) Infection Positively Correlates with Circulating MicroRNA-122 in Patients Sera. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-472031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472031