Mechanism of Inflammation in Age-Related Macular Degeneration : An Up-to-Date on Genetic Landmarks
Joint Authors
Romano, Mario R.
Semeraro, Francesco
Franceschelli, Paola
De Nadai, Katia
Perri, Paolo
Sebastiani, Adolfo
Parmeggiani, Francesco
Sorrentino, Francesco S.
D'Angelo, Sergio
Bonomo Roversi, Elia
Costagliola, Ciro
Rubini, Michele
Incorvaia, Carlo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment among people over 50 years of age, accounting for up to 50% of all cases of legal blindness in Western countries.
Although the aging represents the main determinant of AMD, it must be considered a multifaceted disease caused by interactions among environmental risk factors and genetic backgrounds.
Mounting evidence and/or arguments document the crucial role of inflammation and immune-mediated processes in the pathogenesis of AMD.
Proinflammatory effects secondary to chronic inflammation (e.g., alternative complement activation) and heterogeneous types of oxidative stress (e.g., impaired cholesterol homeostasis) can result in degenerative damages at the level of crucial macular structures, that is photoreceptors, retinal pigment epithelium, and Bruch’s membrane.
In the most recent years, the association of AMD with genes, directly or indirectly, involved in immunoinflammatory pathways is increasingly becoming an essential core for AMD knowledge.
Starting from the key basic-research notions detectable at the root of AMD pathogenesis, the present up-to-date paper reviews the best-known and/or the most attractive genetic findings linked to the mechanisms of inflammation of this complex disease.
American Psychological Association (APA)
Parmeggiani, Francesco& Sorrentino, Francesco S.& Romano, Mario R.& Costagliola, Ciro& Semeraro, Francesco& Incorvaia, Carlo…[et al.]. 2013. Mechanism of Inflammation in Age-Related Macular Degeneration : An Up-to-Date on Genetic Landmarks. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-472039
Modern Language Association (MLA)
Parmeggiani, Francesco…[et al.]. Mechanism of Inflammation in Age-Related Macular Degeneration : An Up-to-Date on Genetic Landmarks. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-472039
American Medical Association (AMA)
Parmeggiani, Francesco& Sorrentino, Francesco S.& Romano, Mario R.& Costagliola, Ciro& Semeraro, Francesco& Incorvaia, Carlo…[et al.]. Mechanism of Inflammation in Age-Related Macular Degeneration : An Up-to-Date on Genetic Landmarks. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-472039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472039