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PPARs : Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling
Joint Authors
de Lange, Pieter
Senese, Rosalba
Lombardi, Assunta
Silvestri, Elena
Moreno, Maria
Cioffi, Federica
Lanni, Antonia
Goglia, Fernando
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptors (PPARs), which are known to regulate lipid homeostasis, are tightly controlled by nutrient availability, and they control nutrient handling.
In this paper, we focus on how nutrients control the expression and action of PPARs and how cellular signaling events regulate the action of PPARs in metabolically active tissues (e.g., liver, skeletal muscle, heart, and white adipose tissue).
We address the structure and function of the PPARs, and their interaction with other nuclear receptors, including PPAR cross-talk.
We further discuss the roles played by different kinase pathways, including the extracellular signal-regulated kinases/mitogen-activated protein kinase (ERK MAPK), AMP-activated protein kinase (AMPK), Akt/protein kinase B (Akt/PKB), and the NAD+-regulated protein deacetylase SIRT1, serving to control the activity of the PPARs themselves as well as that of a key nutrient-related PPAR coactivator, PPARγ coactivator-1α (PGC-1α).
We also highlight how currently applied nutrigenomic strategies will increase our understanding on how nutrients regulate metabolic homeostasis through PPAR signaling.
American Psychological Association (APA)
Moreno, Maria& Lombardi, Assunta& Silvestri, Elena& Senese, Rosalba& Cioffi, Federica& Goglia, Fernando…[et al.]. 2010. PPARs : Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling. PPAR Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-472051
Modern Language Association (MLA)
Moreno, Maria…[et al.]. PPARs : Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling. PPAR Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-472051
American Medical Association (AMA)
Moreno, Maria& Lombardi, Assunta& Silvestri, Elena& Senese, Rosalba& Cioffi, Federica& Goglia, Fernando…[et al.]. PPARs : Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-472051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472051