Release of Danger Signals during Ischemic Storage of the Liver : A Potential Marker of Organ Damage?
Joint Authors
Dahmen, Uta
Jin, Hao
Deng, Meihong
Huang, Hai
Dirsch, Olaf
Bröcker-Preuss, Martina
Liu, Anding
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Liver grafts suffer from unavoidable injury due to ischemia and manipulation before implantation.
Danger signals such as high-mobility group box -1(HMGB1) and macrophage migration inhibitory factor (MIF) play a pivotal role in the immune response.
We characterized the kinetics of their release into the effluent during cold/warm ischemia and additional manipulation-induced mechanical damage.
Furthermore, we evaluated the relationship between HMGB1/MIF release and ischemic/mechanical damage.
Liver enzymes and protein in the effluent increased with increasing ischemia time.
HMGB1/MIF- release correlated with the extent of hepatocellular injury.
With increasing ischemia time and damage, HMGB1 was translocated from the nucleus to the cytoplasma as indicated by weak nuclear and strong cytoplasmic staining.
Enhancement of liver injury by mechanical damage was indicated by an earlier HMGB1 translocation into the cytoplasm and earlier release of danger signals into the effluent.
Our results suggest that determination of HMGB1 and MIF reflects the extent of ischemic injury.
Furthermore, HMGB1and MIF are more sensitive than liver enzymes to detect the additional mechanical damage inflicted on the organ graft during surgical manipulation.
American Psychological Association (APA)
Liu, Anding& Jin, Hao& Dirsch, Olaf& Deng, Meihong& Huang, Hai& Bröcker-Preuss, Martina…[et al.]. 2010. Release of Danger Signals during Ischemic Storage of the Liver : A Potential Marker of Organ Damage?. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-472106
Modern Language Association (MLA)
Liu, Anding…[et al.]. Release of Danger Signals during Ischemic Storage of the Liver : A Potential Marker of Organ Damage?. Mediators of Inflammation No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-472106
American Medical Association (AMA)
Liu, Anding& Jin, Hao& Dirsch, Olaf& Deng, Meihong& Huang, Hai& Bröcker-Preuss, Martina…[et al.]. Release of Danger Signals during Ischemic Storage of the Liver : A Potential Marker of Organ Damage?. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-472106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472106