Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo
Joint Authors
Chmel, Roman
Kuzel, David
Mara, Michal
Horak, Petr
Dundr, Pavel
Kubinova, Kristyna
Hudecek, Robert
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To determine if hormonal treatment induces apoptosis in uterine fibroids.
Methods.
Immunohistochemical examination of fibroid tissue, using avidin-biotin complex and cleaved caspase-3 antibody for detecting apoptosis, was performed in premenopausal women who underwent 12-week treatment with oral SPRM (6 patients with 5 mg and 5 patients with 10 mg of ulipristal acetate per day) or gonadoliberin agonist (GnRHa, 17 patients) and subsequent myomectomy or hysterectomy for symptomatic uterine fibroids.
Ten patients with no presurgical hormonal treatment were used as controls.
Results.
Apoptosis was present in a significantly higher proportion of patients treated with ulipristal acetate compared to GnRHa (P=0.01) and to patients with no hormonal treatment (P=0.01).
In contrast to an AI of 158.9 in SPRM patients, the mean AI was 27.5 and 2.0 in GnRHa and control groups, respectively.
No statistical difference in the AI was observed between the two groups of patients treated with ulipristal acetate (5 mg or 10 mg).
Conclusion.
Treatment with ulipristal acetate induces apoptosis in uterine fibroid cells.
This effect of SPRM may contribute to their positive clinical effect on uterine fibroids.
American Psychological Association (APA)
Horak, Petr& Mara, Michal& Dundr, Pavel& Kubinova, Kristyna& Kuzel, David& Hudecek, Robert…[et al.]. 2012. Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-472107
Modern Language Association (MLA)
Horak, Petr…[et al.]. Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo. International Journal of Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-472107
American Medical Association (AMA)
Horak, Petr& Mara, Michal& Dundr, Pavel& Kubinova, Kristyna& Kuzel, David& Hudecek, Robert…[et al.]. Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-472107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472107