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The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties
Joint Authors
Zhao, Lei
Azelmat, Jabrane
Grenier, Daniel
Yoshioka, Masami
Liao, James
Hinode, Daisuke
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss.
The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different plants, for its capacity to prevent biofilm formation by Fusobacterium nucleatum, to inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion by mucosal cells, and to promote wound healing in a fibroblast model.
Using a microplate colorimetric assay, Rokumigan prevented biofilm formation by F.
nucleatum, while it had no effect on bacterial growth.
Rokumigan inhibited IL-6 secretion in both epithelial cells and fibroblasts stimulated with lipopolysaccharide.
However, it caused no significant inhibition of IL-8 secretion by both cell types.
Rokumigan significantly increased proliferation and migration of gingival fibroblasts in a wound healing assay.
In conclusion, the Kampo formulation Rokumigan, through suppression of biofilm formation by F.
nucleatum, inhibition of IL-6 secretion by gingival epithelial cells and fibroblasts, and promotion of wound healing in a fibroblast model, may have potential application for periodontal diseases.
American Psychological Association (APA)
Liao, James& Azelmat, Jabrane& Zhao, Lei& Yoshioka, Masami& Hinode, Daisuke& Grenier, Daniel. 2014. The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-472113
Modern Language Association (MLA)
Liao, James…[et al.]. The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-472113
American Medical Association (AMA)
Liao, James& Azelmat, Jabrane& Zhao, Lei& Yoshioka, Masami& Hinode, Daisuke& Grenier, Daniel. The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-472113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472113