Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies
Joint Authors
Stuart, Jordyn M.
Paris, Jason J.
Bradshaw, Heather B.
Frye, Cheryl
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Endogenous cannabinoids (eCBs) are involved in the development and regulation of reproductive behaviors.
Likewise, prostaglandins (PGs) drive sexual differentiation and initiation of ovulation.
Here, we use lipidomics strategies to test the hypotheses that mating immediately activates the biosynthesis and/or metabolism of eCBs and PGs and that specific mating strategies differentially regulate these lipids in the brain.
Methods.
Lipid extractions and tandem mass spectrometric analysis were performed on brains from proestrous rats that had experienced one of two mating strategies (paced or standard mating) and two nonmated groups (chamber exposed and home cage controls).
Levels of PGs (PGE2 and PGF2alpha), eCBs (AEA and 2-AG, N-arachidonoyl glycine), and 4 related lipids (4 N-acylethanolamides) were measured in olfactory bulb, hypothalamus, hippocampus, thalamus, striatum, midbrain, cerebellum, and brainstem.
Results.
Overall, levels of these lipids were significantly lower among paced compared to standard mated rats with the most dramatic decreases observed in brainstem, hippocampus, midbrain, and striatum.
However, chamber exposed rats had significantly higher levels of these lipids compared to home cage controls and paced mated wherein the hippocampus showed the largest increases.
Conclusions.
These data demonstrate that mating strategies and exposure to mating arenas influence lipid signaling in the brain.
American Psychological Association (APA)
Stuart, Jordyn M.& Paris, Jason J.& Frye, Cheryl& Bradshaw, Heather B.. 2013. Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-472120
Modern Language Association (MLA)
Stuart, Jordyn M.…[et al.]. Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies. International Journal of Endocrinology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-472120
American Medical Association (AMA)
Stuart, Jordyn M.& Paris, Jason J.& Frye, Cheryl& Bradshaw, Heather B.. Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-472120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472120