Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
Joint Authors
Berge, Rolf Kristian
Syversen, Unni
Reseland, Janne Elin
Westbroek, Irene
Fossmark, Reidar
Stunes, Astrid Kamilla
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA).
Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months.
Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined.
Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed.
Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls.
The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM.
However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM.
TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.
American Psychological Association (APA)
Stunes, Astrid Kamilla& Westbroek, Irene& Fossmark, Reidar& Berge, Rolf Kristian& Reseland, Janne Elin& Syversen, Unni. 2011. Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats. PPAR Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-472138
Modern Language Association (MLA)
Stunes, Astrid Kamilla…[et al.]. Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats. PPAR Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-472138
American Medical Association (AMA)
Stunes, Astrid Kamilla& Westbroek, Irene& Fossmark, Reidar& Berge, Rolf Kristian& Reseland, Janne Elin& Syversen, Unni. Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-472138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472138