Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC
Joint Authors
Goudar, Ranjit K.
Bukhari, Ali A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In recent years, major strides in cancer research have made it possible to select personalized chemotherapy recommendations based on an individual patient’s tumor biology.
The prognostic and/or predictive ability of biomarkers seeks to tailor the use of targeted chemotherapy and can result in improved clinical outcomes with reduced toxicity.
A proliferation of new technology and pharmacotherapeutics in the setting of current FDA Clinical Laboratory Improvement Amendment (CLIA) standards has resulted in a recent surge in direct-to-physician biomarker tests.
However, in the absence of clinical validation, there is the concern that the biomarkers may be utilized prematurely, resulting in improper chemotherapy selection and patient harm.
Thymidylate synthase (TS) has been marketed as a predictive biomarker for the use of pemetrexed in NSCLC.
We will examine the evidence behind the use of TS as a predictive biomarker to predict response to pemetrexed in NSCLC.
At this time, the evidence does not currently support using TS assays to guide chemotherapy selection outside of a clinical research protocol.
American Psychological Association (APA)
Bukhari, Ali A.& Goudar, Ranjit K.. 2013. Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC. Lung Cancer International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472143
Modern Language Association (MLA)
Bukhari, Ali A.& Goudar, Ranjit K.. Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC. Lung Cancer International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-472143
American Medical Association (AMA)
Bukhari, Ali A.& Goudar, Ranjit K.. Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC. Lung Cancer International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472143