PPARγ : The Portrait of a Target Ally to Cancer Chemopreventive Agents
Joint Authors
Sainis, Ioannis
Vareli, Katerina
Karavasilis, Vasilios
Briasoulis, Evangelos
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-gamma (PPARγ), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents.
PPARγ was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later on, it became evident that it is also involved in cell differentiation, apoptosis, and angiogenesis, biological processes which are deregulated in cancer.
It is now established that PPARγ ligands can induce cell differentiation and yield early antineoplastic effects in several tumor types.
Moreover, several bioactive natural products with cancer protecting potential are shown to operate through activation of PPARγ.
Overall, PPARγ appears to be a prevalent target ally to cancer chemopreventive agents and therefore pursuing research in this area is of great relevance.
American Psychological Association (APA)
Sainis, Ioannis& Vareli, Katerina& Karavasilis, Vasilios& Briasoulis, Evangelos. 2008. PPARγ : The Portrait of a Target Ally to Cancer Chemopreventive Agents. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-472148
Modern Language Association (MLA)
Sainis, Ioannis…[et al.]. PPARγ : The Portrait of a Target Ally to Cancer Chemopreventive Agents. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-472148
American Medical Association (AMA)
Sainis, Ioannis& Vareli, Katerina& Karavasilis, Vasilios& Briasoulis, Evangelos. PPARγ : The Portrait of a Target Ally to Cancer Chemopreventive Agents. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-472148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472148