WF10 Stimulates NK Cell Cytotoxicity by Increasing LFA-1-Mediated Adhesion to Tumor Cells
Joint Authors
Giese, Thomas
Kühne, Louisa
Watzl, Carsten
Samstag, Yvonne
Meuer, Stefan
Konstandin, Mathias
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The redox-active chlorite-based drug WF10 (Immunokine) was shown to have modulatory effects on both the innate and adaptive immune system in vitro and in vivo.
Animal studies suggest that WF10 enhances immunity against tumors.
One possible explanation for such an effect is that WF10 stimulates natural killer cell cytotoxicity against malignant cells.
Here, we show that WF10 regulates human NK cell cytotoxicity in a time-dependent manner, following an S-shaped kinetic with an initial stimulation of activity followed by a decrease in activity relative to the untreated controls.
WF10 does not activate NK cells on its own but co-stimulates NK cell activation mediated by different activating receptors.
This is mediated by enhancing NK cell adhesion to target cells through promoting the activation of the integrin LFA-1.
These data demonstrate a direct effect of WF10 on the cytotoxicity of human NK cells.
American Psychological Association (APA)
Kühne, Louisa& Konstandin, Mathias& Samstag, Yvonne& Meuer, Stefan& Giese, Thomas& Watzl, Carsten. 2011. WF10 Stimulates NK Cell Cytotoxicity by Increasing LFA-1-Mediated Adhesion to Tumor Cells. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-472163
Modern Language Association (MLA)
Kühne, Louisa…[et al.]. WF10 Stimulates NK Cell Cytotoxicity by Increasing LFA-1-Mediated Adhesion to Tumor Cells. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-472163
American Medical Association (AMA)
Kühne, Louisa& Konstandin, Mathias& Samstag, Yvonne& Meuer, Stefan& Giese, Thomas& Watzl, Carsten. WF10 Stimulates NK Cell Cytotoxicity by Increasing LFA-1-Mediated Adhesion to Tumor Cells. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-472163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472163