Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis
Joint Authors
Milewski, Robert
Hryniewicz, Andrzej
Konstantynowicz, Jerzy
Bossowski, Artur
Łuczyński, Włodzimierz
Piotrowska-Jastrzębska, Janina
Dobreńko, Elżbieta
Kowal-Bielecka, Otylia
Głowińska-Olszewska, Barbara
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
We aimed to determine the prevalence of excess body mass in juvenile idiopathic arthritis (JIA) children and to investigate the influence of obesity into the early, subclinical changes in cardiovascular system in these patients.
Methods.
Fifty-eight JIA patients, aged median 13 years, were compared to 36 healthy controls.
Traditional cardiovascular risk factors and inflammatory markers (hsCRP, IL-6, TNFα, adiponectin) were studied together with IMT (intima-media thickness), FMD (flow mediated dilation), and LVMi (left ventricle mass index) as surrogate markers of subclinical atherosclerosis.
Results.
Thirteen JIA children (22%) were obese and had increased systolic blood pressure, cholesterol, triglycerides, insulin, HOMA, hsCRP, and IL-6 compared to nonobese JIA and controls.
FMD was decreased compared to nonobese JIA and controls, whereas IMT and LVMi were increased.
In multivariate regression analysis, TNFα, SDS-BMI, and systolic blood pressure were independent predictors of early CV changes in JIA.
Conclusions.
Coincident obesity is common in JIA children and is associated with insulin resistance, dyslipidemia, and increased levels of inflammatory markers leading to early changes in cardiovascular system.
Thus, medical care of children with JIA should include strategies preventing cardiovascular disease by maintenance of adequate body weight.
American Psychological Association (APA)
Głowińska-Olszewska, Barbara& Bossowski, Artur& Dobreńko, Elżbieta& Hryniewicz, Andrzej& Konstantynowicz, Jerzy& Milewski, Robert…[et al.]. 2013. Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-472164
Modern Language Association (MLA)
Głowińska-Olszewska, Barbara…[et al.]. Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-472164
American Medical Association (AMA)
Głowińska-Olszewska, Barbara& Bossowski, Artur& Dobreńko, Elżbieta& Hryniewicz, Andrzej& Konstantynowicz, Jerzy& Milewski, Robert…[et al.]. Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-472164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472164