In Vitro Investigation of a Terbinafine Impregnated Subcutaneous Implant for Veterinary Use
Joint Authors
Yarbrogh, J.
Souza, M. J.
Cairns, T.
Cox, S. K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A terbinafine impregnated subcutaneous implant was evaluated to determine if drug was released into isotonic saline over the course of 6 months at two different temperatures, 37°C and 4°C.
These temperatures were chosen to simulate the nonhibernating (37°C) and hibernating body (4°C) temperatures of little brown bats (Myotis lucifugus).
Insectivorous bats of North America, including little brown bats, have been devastated by white nose syndrome, a fungal infection caused by Geomyces destructans.
No treatments exist for bats infected with G.
destructans.
Implants were placed into isotonic saline; samples were collected once per week and analyzed with HPLC to determine terbinafine concentrations.
The mean amount of terbinafine released weekly across the 28 weeks was approximately 1.7 μg at 4°C and 4.3 μg at 37°C.
Although significant differences in the amount released did occur at some time points, these differences were not consistently greater or less at either of the temperatures.
This study showed that terbinafine was released from an impregnated implant over the course of 6 months at concentrations ranging from 0.02 to 0.06 μg/mL depending on temperature, which may be appropriate for little brown bats (Myotis lucifugus) infected with Geomyces destructans, the etiologic agent of white nose syndrome.
American Psychological Association (APA)
Souza, M. J.& Cairns, T.& Yarbrogh, J.& Cox, S. K.. 2012. In Vitro Investigation of a Terbinafine Impregnated Subcutaneous Implant for Veterinary Use. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-472166
Modern Language Association (MLA)
Souza, M. J.…[et al.]. In Vitro Investigation of a Terbinafine Impregnated Subcutaneous Implant for Veterinary Use. Journal of Drug Delivery No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-472166
American Medical Association (AMA)
Souza, M. J.& Cairns, T.& Yarbrogh, J.& Cox, S. K.. In Vitro Investigation of a Terbinafine Impregnated Subcutaneous Implant for Veterinary Use. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-472166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472166