![](/images/graphics-bg.png)
Synthesis and Evaluation of Novel Fluorinated 2-Styrylchromones as Antibacterial Agents
Joint Authors
Momin, Mehbub
Koorbanally, Neil A.
Ramjugernath, Deresh
Chenia, Hafizah
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A range of fluorinated 2-styrylchromones (5a–g) of which six were new (5a–f) were prepared in three steps using the Baker-Venkataraman rearrangement along with two methoxylated derivatives (5h-i) and a methylenedioxy derivative (5j) and screened for their antibacterial activity using Gram-positive bacteria (Staphylococcus aureus, sciuri, and xylosus as well as Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia).
The compounds were most effective against B.
subtilis followed by S.
aureus and a single strain of E.
coli (ATCC 25922).
Difluorination on the phenyl ring was shown to enhance antibacterial activity, and fluorine substitution at the 6 position was shown to be far superior to substitution at the 7 position.
In comparison to tetracycline, the activity indices of the fluorinated styrylchromones ranged from 0.50 to 0.75 against B.
subtilis.
The crystal structure of 2′-fluoro-2-styrylchromone is also presented, and the molecule was shown to be planar.
American Psychological Association (APA)
Momin, Mehbub& Ramjugernath, Deresh& Chenia, Hafizah& Koorbanally, Neil A.. 2013. Synthesis and Evaluation of Novel Fluorinated 2-Styrylchromones as Antibacterial Agents. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-472172
Modern Language Association (MLA)
Momin, Mehbub…[et al.]. Synthesis and Evaluation of Novel Fluorinated 2-Styrylchromones as Antibacterial Agents. Journal of Chemistry No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-472172
American Medical Association (AMA)
Momin, Mehbub& Ramjugernath, Deresh& Chenia, Hafizah& Koorbanally, Neil A.. Synthesis and Evaluation of Novel Fluorinated 2-Styrylchromones as Antibacterial Agents. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-472172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472172