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Parkinson's Disease and Systemic Inflammation
Joint Authors
Tarelli, Rodolfo
Ferrari, Carina C.
Source
International Journal of Antennas and Propagation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Peripheral inflammation triggers exacerbation in the central brain's ongoing damage in several neurodegenerative diseases.
Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain.
In Parkinson's disease (PD), inflammation was mainly associated with microglia activation that can underlie the neurodegeneration of neurons in the substantia nigra (SN).
Peripheral inflammation can transform the “primed” microglia into an “active” state, which can trigger stronger responses dealing with neurodegenerative processes.
Numerous evidences show that systemic inflammatory processes exacerbate ongoing neurodegeneration in PD patient and animal models.
Anti-inflammatory treatment in PD patients exerts a neuroprotective effect.
In the present paper, we analyse the effect of peripheral infections in the etiology and progression in PD patients and animal models, suggesting that these peripheral immune challenges can exacerbate the symptoms in the disease.
American Psychological Association (APA)
Ferrari, Carina C.& Tarelli, Rodolfo. 2011. Parkinson's Disease and Systemic Inflammation. International Journal of Antennas and Propagation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-472178
Modern Language Association (MLA)
Ferrari, Carina C.& Tarelli, Rodolfo. Parkinson's Disease and Systemic Inflammation. International Journal of Antennas and Propagation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-472178
American Medical Association (AMA)
Ferrari, Carina C.& Tarelli, Rodolfo. Parkinson's Disease and Systemic Inflammation. International Journal of Antennas and Propagation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-472178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472178