α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies
Joint Authors
Kasuga, Kensaku
Nishizawa, Masatoyo
Ikeuchi, Takeshi
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dementia with Lewy bodies (DLB) is a common subtype of dementia in the elderly.
DLB is neuropathologically characterized by the presence of Lewy bodies and Lewy neurites, both of which are composed of α-synuclein.
Although α-synuclein was initially considered to be an exclusively intracellular protein, it has been found to be secreted into biological fluids.
α-Synuclein in biological fluids such as cerebrospinal fluid (CSF) and blood has been discussed as a potential biomarker of DLB and α-synuclein-related disorders, because α-synuclein is characteristically accumulated in the brain of patients with these disorders.
The α-synuclein level in CSF has been examined by several investigators, and the majority of studies have shown a reduction in CSF α-synuclein level in DLB and α-synuclein-related disorders.
Discrepant findings of studies of plasma α-synuclein level in patients with DLB have been reported.
Because the level of α-synuclein stored in red blood cells is considerably high, blood contamination and haemolysis during sample collection and processing should be considered as a confounding factor for quantification of α-synuclein.
Here, the recent progress in the studies of α-synuclein as a biomarker of DLB and their potential clinical applications are reviewed.
American Psychological Association (APA)
Kasuga, Kensaku& Nishizawa, Masatoyo& Ikeuchi, Takeshi. 2012. α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472208
Modern Language Association (MLA)
Kasuga, Kensaku…[et al.]. α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472208
American Medical Association (AMA)
Kasuga, Kensaku& Nishizawa, Masatoyo& Ikeuchi, Takeshi. α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472208