Effects of Single Pill-Based Combination Therapy of Amlodipine and Atorvastatin on Within-Visit Blood Pressure Variability and Parameters of Renal and Vascular Function in Hypertensive Patients with Chronic Kidney Disease
Joint Authors
Ohsawa, Masato
Dejima, Toru
Tamura, Kouichi
Toya, Yoshiyuki
Azushima, Kengo
Wakui, Hiromichi
Umemura, Satoshi
Kanaoka, Tomohiko
Kobayashi, Ryu
Maeda, Akinobu
Uneda, Kazushi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Both strict blood pressure (BP) control and improvements in BP profile such as BP variability are important for suppression of renal deterioration and cardiovascular complication in hypertension and chronic kidney disease (CKD).
In the present study, we examined the beneficial effects of the single pill-based combination therapy of amlodipine and atorvastatin on achievement of the target BP and clinic BP profile, as well as markers of vascular and renal damages in twenty hypertensive CKD patients.
The combination therapy with amlodipine and atorvastatin for 16 weeks significantly decreased clinic BP, and achievement of target BP control was attained in an average of 45% after the combination therapy in spite of the presence of no achievement at baseline.
In addition, the combination therapy significantly decreased the within-visit BP variability.
With respect to the effects on renal damage markers, combination therapy with amlodipine and atorvastatin for 16 weeks significantly decreased albuminuria (urine albumin-to-creatinine ratio, 1034±1480 versus 733±1218 mg/g-Cr, P<0.05) without decline in estimated glomerular filtration rate.
Concerning parameters of vascular function, the combination therapy significantly improved both brachial-ankle pulse wave velocity (baPWV) and central systolic BP (cSBP) (baPWV, 1903±353 versus 1786±382 cm/s, P<0.05; cSBP, 148±19 versus 129±23 mmHg, P<0.01).
Collectively, these results suggest that the combination therapy with amlodipine and atorvastatin may exert additional beneficial effects on renal and vascular damages as well as BP profile in addition to BP lowering in hypertension with CKD.
American Psychological Association (APA)
Azushima, Kengo& Uneda, Kazushi& Tamura, Kouichi& Wakui, Hiromichi& Ohsawa, Masato& Kobayashi, Ryu…[et al.]. 2014. Effects of Single Pill-Based Combination Therapy of Amlodipine and Atorvastatin on Within-Visit Blood Pressure Variability and Parameters of Renal and Vascular Function in Hypertensive Patients with Chronic Kidney Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-472214
Modern Language Association (MLA)
Azushima, Kengo…[et al.]. Effects of Single Pill-Based Combination Therapy of Amlodipine and Atorvastatin on Within-Visit Blood Pressure Variability and Parameters of Renal and Vascular Function in Hypertensive Patients with Chronic Kidney Disease. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-472214
American Medical Association (AMA)
Azushima, Kengo& Uneda, Kazushi& Tamura, Kouichi& Wakui, Hiromichi& Ohsawa, Masato& Kobayashi, Ryu…[et al.]. Effects of Single Pill-Based Combination Therapy of Amlodipine and Atorvastatin on Within-Visit Blood Pressure Variability and Parameters of Renal and Vascular Function in Hypertensive Patients with Chronic Kidney Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-472214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472214