Paleopathology of Human Tuberculosis and the Potential Role of Climate
Joint Authors
Nerlich, Andreas G.
Lösch, Sandra
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Both origin and evolution of tuberculosis and its pathogens (Mycobacterium tuberculosis complex) are not fully understood.
The paleopathological investigation of human remains offers a unique insight into the molecular evolution and spread including correlative data of the environment.
The molecular analysis of material from Egypt (3000–500 BC), Sudan (200–600 AD), Hungary (600–1700 AD), Latvia (1200–1600 AD), and South Germany (1400–1800 AD) urprisingly revealed constantly high frequencies of tuberculosis in all different time periods excluding significant environmental influence on tuberculosis spread.
The typing of various mycobacteria strains provides evidence for ancestral M.
tuberculosis strains in Pre- to early Egyptian dynastic material (3500–2650 BC), while typical M.
africanum signatures were detected in a Middle Kingdom tomb (2050–1650 BC).
Samples from the New Kingdom to Late Period (1500–500 BC) indicated modern M.
tuberculosis strains.
No evidence was seen for M.
bovis in Egyptian material while M.
bovis signatures were first identified in Siberian biomaterial dating 2000 years before present.
These results contraindicates the theory that M.
tuberculosis evolved from M.
bovis during early domestication in the region of the “Fertile Crescent,” but supports the scenario that M.
tuberculosis probably derived from an ancestral progenitor strain.
The environmental influence of this evolutionary scenario deserves continuing intense evaluation.
American Psychological Association (APA)
Nerlich, Andreas G.& Lösch, Sandra. 2009. Paleopathology of Human Tuberculosis and the Potential Role of Climate. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-472230
Modern Language Association (MLA)
Nerlich, Andreas G.& Lösch, Sandra. Paleopathology of Human Tuberculosis and the Potential Role of Climate. Interdisciplinary Perspectives on Infectious Diseases No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-472230
American Medical Association (AMA)
Nerlich, Andreas G.& Lösch, Sandra. Paleopathology of Human Tuberculosis and the Potential Role of Climate. Interdisciplinary Perspectives on Infectious Diseases. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-472230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472230