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Toll-Like Receptors : Role in Dermatological Disease
Joint Authors
Flach, Tracy L.
Hari, Aswin
Shi, Yan
Mydlarski, P. Régine
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-22
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes.
In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors.
Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells.
TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems.
Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms.
In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics.
American Psychological Association (APA)
Hari, Aswin& Flach, Tracy L.& Shi, Yan& Mydlarski, P. Régine. 2010. Toll-Like Receptors : Role in Dermatological Disease. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-472236
Modern Language Association (MLA)
Hari, Aswin…[et al.]. Toll-Like Receptors : Role in Dermatological Disease. Mediators of Inflammation No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-472236
American Medical Association (AMA)
Hari, Aswin& Flach, Tracy L.& Shi, Yan& Mydlarski, P. Régine. Toll-Like Receptors : Role in Dermatological Disease. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-472236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472236