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Effects of Assisted Reproduction Technology on Placental Imprinted Gene Expression
Joint Authors
Kitamura, Mamoru
Katagiri, Yukiko
Fukuda, Yusuke
Matsue, Yoichi
Morita, Mineto
So, Akiko
Aoki, Chizu
Tamaki-Ishihara, Yuko
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We used placental tissue to compare the imprinted gene expression of IGF2, H19, KCNQ1OT1, and CDKN1C of singletons conceived via assisted reproduction technology (ART) with that of spontaneously conceived (SC) singletons.
Of 989 singletons examined (ART n=65; SC n=924), neonatal weight was significantly lower (P<.001) in the ART group than in the SC group, but placental weight showed no significant difference.
Gene expression analyzed by real-time PCR was similar for both groups with appropriate-for-date (AFD) birth weight.
H19 expression was suppressed in fetal growth retardation (FGR) cases in the ART and SC groups compared with AFD cases (P<.02 and P<.05, resp.).
In contrast, CDKN1C expression was suppressed in FGR cases in the ART group (P<.01), while KCNQ1OT1 expression was hyperexpressed in FGR cases in the SC group (P<.05).
As imprinted gene expression patterns differed between the ART and SC groups, we speculate that ART modifies epigenetic status even though the possibilities always exist.
American Psychological Association (APA)
Katagiri, Yukiko& Aoki, Chizu& Tamaki-Ishihara, Yuko& Fukuda, Yusuke& Kitamura, Mamoru& Matsue, Yoichi…[et al.]. 2010. Effects of Assisted Reproduction Technology on Placental Imprinted Gene Expression. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-472268
Modern Language Association (MLA)
Katagiri, Yukiko…[et al.]. Effects of Assisted Reproduction Technology on Placental Imprinted Gene Expression. Obstetrics and Gynecology International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-472268
American Medical Association (AMA)
Katagiri, Yukiko& Aoki, Chizu& Tamaki-Ishihara, Yuko& Fukuda, Yusuke& Kitamura, Mamoru& Matsue, Yoichi…[et al.]. Effects of Assisted Reproduction Technology on Placental Imprinted Gene Expression. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-472268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472268