Protective Function of STAT3 in CVB3-Induced Myocarditis
Joint Authors
Pauschinger, Matthias
Klingel, Karin
Tschöpe, Carsten
Hilbrandt, Moritz
Lindner, Diana
Becher, P. Moritz
Hilfiker-Kleiner, Denise
Schultheiss, Heinz-Peter
Westermann, Dirk
Marggraf, Katharina
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The transcription factor signal transducer and activator of transcription 3 (STAT3) is an important mediator of the inflammatory process.
We investigated the role of STAT3 in viral myocarditis and its possible role in the development to dilated cardiomyopathy.
We used STAT3-deficent mice with a cardiomyocyte-restricted knockout and induced a viral myocarditis using Coxsackievirus B3 (CVB3) which induced a severe inflammation during the acute phase of the viral myocarditis.
A complete virus clearance and an attenuated inflammation were examined in both groups WT and STAT3 KO mice 4 weeks after infection, but the cardiac function in STAT3 KO mice was significantly decreased in contrast to the infected WT mice.
Interestingly, an increased expression of collagen I was detected in STAT3 KO mice compared to WT mice 4 weeks after CVB3 infection.
Furthermore, the matrix degradation was reduced in STAT3 KO mice which might be an explanation for the observed matrix deposition.
Consequently, we here demonstrate the protective function of STAT3 in CVB3-induced myocarditis.
Since the cardiomyocyte-restricted knockout leads to an increased fibrosis, it can be assumed that STAT3 signalling in cardiomyocytes protects the heart against increased fibrosis through paracrine effects.
American Psychological Association (APA)
Lindner, Diana& Hilbrandt, Moritz& Marggraf, Katharina& Becher, P. Moritz& Hilfiker-Kleiner, Denise& Klingel, Karin…[et al.]. 2012. Protective Function of STAT3 in CVB3-Induced Myocarditis. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-472280
Modern Language Association (MLA)
Lindner, Diana…[et al.]. Protective Function of STAT3 in CVB3-Induced Myocarditis. Cardiology Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-472280
American Medical Association (AMA)
Lindner, Diana& Hilbrandt, Moritz& Marggraf, Katharina& Becher, P. Moritz& Hilfiker-Kleiner, Denise& Klingel, Karin…[et al.]. Protective Function of STAT3 in CVB3-Induced Myocarditis. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-472280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472280