The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis

Joint Authors

Smits, Anne
Allegaert, Karel
van Calsteren, Kristel
Verbesselt, Rene
de Hoon, Jan
Kulo, Aida
Devlieger, Roland

Source

Journal of Biomedicine and Biotechnology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-20

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Pharmacokinetics is a first, but essential step to improve population-tailored postoperative analgesia, also after Caesarean delivery.

We therefore aimed to quantify the impact of caesarean delivery on the pharmacokinetics of intravenous (iv) paracetamol (2 g, single dose) and iv ketorolac tromethamine (30 mg, single dose) in 2 cohorts eachof 8 women at caesarean delivery and to compare these findings with postpartum to quantify intrapatient changes.

We documented a higher median paracetamol clearance at delivery when compared to 10–15 weeks postpartum (11.7 to 6.4 L/h⋅m2, P<0.01), even after correction for weight-related changes.

Similar conclusions were drawn for ketorolac: median clearance was higher at delivery with a subsequent decrease (2.03 to 1.43 L/h⋅m2, P<0.05) in postpartum (17–23 weeks).

These differences likely reflect pregnancy- and caesarean-delivery-related changes in drug disposition.

Moreover, postpartum paracetamol clearance was significantly lower when compared to estimates published in healthy young volunteers (6.4 versus 9.6 L/h⋅m2), while this was not the case for ketorolac (1.43 versus 1.48 L/h⋅m2).

This suggests that postpartum is another specific status in young women that merits focused, compound-specific pharmacokinetic evaluation.

American Psychological Association (APA)

Kulo, Aida& van Calsteren, Kristel& Verbesselt, Rene& Smits, Anne& Devlieger, Roland& de Hoon, Jan…[et al.]. 2012. The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472283

Modern Language Association (MLA)

Kulo, Aida…[et al.]. The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-472283

American Medical Association (AMA)

Kulo, Aida& van Calsteren, Kristel& Verbesselt, Rene& Smits, Anne& Devlieger, Roland& de Hoon, Jan…[et al.]. The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472283

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-472283