The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis
Joint Authors
Smits, Anne
Allegaert, Karel
van Calsteren, Kristel
Verbesselt, Rene
de Hoon, Jan
Kulo, Aida
Devlieger, Roland
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pharmacokinetics is a first, but essential step to improve population-tailored postoperative analgesia, also after Caesarean delivery.
We therefore aimed to quantify the impact of caesarean delivery on the pharmacokinetics of intravenous (iv) paracetamol (2 g, single dose) and iv ketorolac tromethamine (30 mg, single dose) in 2 cohorts eachof 8 women at caesarean delivery and to compare these findings with postpartum to quantify intrapatient changes.
We documented a higher median paracetamol clearance at delivery when compared to 10–15 weeks postpartum (11.7 to 6.4 L/h⋅m2, P<0.01), even after correction for weight-related changes.
Similar conclusions were drawn for ketorolac: median clearance was higher at delivery with a subsequent decrease (2.03 to 1.43 L/h⋅m2, P<0.05) in postpartum (17–23 weeks).
These differences likely reflect pregnancy- and caesarean-delivery-related changes in drug disposition.
Moreover, postpartum paracetamol clearance was significantly lower when compared to estimates published in healthy young volunteers (6.4 versus 9.6 L/h⋅m2), while this was not the case for ketorolac (1.43 versus 1.48 L/h⋅m2).
This suggests that postpartum is another specific status in young women that merits focused, compound-specific pharmacokinetic evaluation.
American Psychological Association (APA)
Kulo, Aida& van Calsteren, Kristel& Verbesselt, Rene& Smits, Anne& Devlieger, Roland& de Hoon, Jan…[et al.]. 2012. The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472283
Modern Language Association (MLA)
Kulo, Aida…[et al.]. The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-472283
American Medical Association (AMA)
Kulo, Aida& van Calsteren, Kristel& Verbesselt, Rene& Smits, Anne& Devlieger, Roland& de Hoon, Jan…[et al.]. The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics : A Paired Analysis. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472283