The Plasminogen System in Regulating Stem Cell Mobilization
Joint Authors
Hoover-Plow, Jane
Gong, Yanqing
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The treatment of patients with hematopoietic progenitor and stem cells (HPSCs) to reconstitute hematopoiesis after myeloablative therapy or to repair ischemia after myocardial infarction has significantly improved clinical outcomes.
Successful blood or bone marrow transplants require a sufficient number of HPSCs capable of homing to the injured site to regenerate tissue.
Granulocyte-colony stimulating factor (G-CSF) is widely used clinically for stem cell mobilization.
However, in some patients the response is poor, thus a better understanding of the mechanisms underlying G-CSF-regulated stem cell mobilization is needed.
The pasminogen (Plg) system is the primary fibrinolytic pathway responsible for clot dissolution after thrombosis.
Recent evidence suggests that Plg plays a pivotal role in stem cell mobilization from the bone marrow to the peripheral circulation, particularly in HPSC mobilization in response to G-CSF.
This paper will discuss the potential mechanisms by which the Plg system regulates stem cell mobilization, focusing on stepwise proteolysis and signal transduction during HPSC egress from their bone marrow niche.
Clear elucidation of the underlying mechanisms may lead to the development of new Plg-based therapeutic strategies to improve stem cell mobilization in treating hematological and cardiovascular diseases.
American Psychological Association (APA)
Gong, Yanqing& Hoover-Plow, Jane. 2012. The Plasminogen System in Regulating Stem Cell Mobilization. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-472309
Modern Language Association (MLA)
Gong, Yanqing& Hoover-Plow, Jane. The Plasminogen System in Regulating Stem Cell Mobilization. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-472309
American Medical Association (AMA)
Gong, Yanqing& Hoover-Plow, Jane. The Plasminogen System in Regulating Stem Cell Mobilization. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-472309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472309