TSH Measurement and Its Implications for Personalised Clinical Decision-Making
Joint Authors
Midgley, John E. M.
Hoermann, Rudolf
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Advances in assay technology have promoted thyrotropin (TSH) measurements from participation in a multi-analyte assessment of thyroid function to a statistically defined screening parameter in its own right.
While this approach has been successful in many ways, it has some grave limitations.
This includes the basic question of what constitutes an agreed reference range and the fact that the population-based reference range by far exceeds the variation of the intraindividual set point.
Both problems result in a potential misdiagnosis of normal and pathological thyroid function in a substantial proportion of patients.
From a physiological perspective, TSH plays an integrated role in thyroid homeostasis.
Few attempts have been made to adopt physiological insights into thyroid homeostasis for medical decision-making.
Some emerging novel findings question the widely assumed log-linear TSH-FT4 relationship over the entire thyroid function spectrum.
This data favours more complex hierarchically structured models.
With a better understanding of its role in thyroid homeostasis in thyroid health and disease, TSH can be revisited in the context of thyroid regulation.
This, in turn, could help overcome some of the limitations arising from its isolated statistical use and offer new prospects towards a more personalised interpretation of thyroid test results.
American Psychological Association (APA)
Hoermann, Rudolf& Midgley, John E. M.. 2012. TSH Measurement and Its Implications for Personalised Clinical Decision-Making. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472318
Modern Language Association (MLA)
Hoermann, Rudolf& Midgley, John E. M.. TSH Measurement and Its Implications for Personalised Clinical Decision-Making. Journal of Thyroid Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472318
American Medical Association (AMA)
Hoermann, Rudolf& Midgley, John E. M.. TSH Measurement and Its Implications for Personalised Clinical Decision-Making. Journal of Thyroid Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472318