Environment, Leptin Sensitivity, and Hypothalamic Plasticity
Joint Authors
Maffei, Margherita
Pizzorusso, Tommaso
Mainardi, Marco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Regulation of feeding behavior has been a crucial step in the interplay between leptin and the arcuate nucleus of the hypothalamus (ARC).
On one hand, the basic mechanisms regulating central and peripheral action of leptin are becoming increasingly clear.
On the other hand, knowledge on how brain sensitivity to leptin can be modulated is only beginning to accumulate.
This point is of paramount importance if one considers that pathologically obese subjects have high levels of plasmatic leptin.
A possible strategy for exploring neural plasticity in the ARC is to act on environmental stimuli.
This can be achieved with various protocols, namely, physical exercise, high-fat diet, caloric restriction, and environmental enrichment.
Use of these protocols can, in turn, be exploited to isolate key molecules with translational potential.
In the present review, we summarize present knowledge about the mechanisms of plasticity induced by the environment in the ARC.
In addition, we also address the role of leptin in extrahypothalamic plasticity, in order to propose an integrated view of how a single diffusible factor can regulate diverse brain functions.
American Psychological Association (APA)
Mainardi, Marco& Pizzorusso, Tommaso& Maffei, Margherita. 2013. Environment, Leptin Sensitivity, and Hypothalamic Plasticity. Neural Plasticity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472321
Modern Language Association (MLA)
Mainardi, Marco…[et al.]. Environment, Leptin Sensitivity, and Hypothalamic Plasticity. Neural Plasticity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472321
American Medical Association (AMA)
Mainardi, Marco& Pizzorusso, Tommaso& Maffei, Margherita. Environment, Leptin Sensitivity, and Hypothalamic Plasticity. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472321