The Epstein-Barr Virus EBNA1 Protein
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Epstein-Barr virus (EBV) is a widespread human herpes virus that immortalizes cells as part of its latent infection and is a causative agent in the development of several types of lymphomas and carcinomas.
Replication and stable persistence of the EBV genomes in latent infection require the viral EBNA1 protein, which binds specific DNA sequences in the viral DNA.
While the roles of EBNA1 were initially thought to be limited to effects on the viral genomes, more recently EBNA1 has been found to have multiple effects on cellular proteins and pathways that may also be important for viral persistence.
In addition, a role for EBNA1 in lytic infection has been recently identified.
The multiple roles of EBNA1 in EBV infection are the subject of this paper.
American Psychological Association (APA)
Frappier, Lori. 2012. The Epstein-Barr Virus EBNA1 Protein. Scientifica،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-472334
Modern Language Association (MLA)
Frappier, Lori. The Epstein-Barr Virus EBNA1 Protein. Scientifica No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-472334
American Medical Association (AMA)
Frappier, Lori. The Epstein-Barr Virus EBNA1 Protein. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-472334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472334