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Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344.
The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature.
The resinate was evaluated for micromeritic properties and characterized using XRPD and IR.
For resinate sustained release tablets were formulated using hydoxypropyl methylcellulose K100M.
The tablets were evaluated for hardness, thickness, friability, drug content, weight variation, and in vitro drug release.
Tablets thus formulated (Batch T-3) provided sustained release of drug over a period of 12 h.
The release of Betahistine HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium.
Results showed that Betahistine HCl was formulated into a sustained dosage form as an alternative to the conventional tablet.
American Psychological Association (APA)
Wagh, Vijay D.& Pawar, Nilesh. 2012. Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472341
Modern Language Association (MLA)
Wagh, Vijay D.& Pawar, Nilesh. Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344. ISRN Pharmaceutics No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-472341
American Medical Association (AMA)
Wagh, Vijay D.& Pawar, Nilesh. Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472341