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The Role of Atoh1 in Mucous Cell Metaplasia
Joint Authors
Lin, Jizhen
Suzuki, Motohiko
Nakamura, Yoshihisa
Komori, Masahiro
Yokota, Makoto
Hamajima, Yuki
Source
International Journal of Otolaryngology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease.
However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media.
Numerous studies of intestinal epithelial homeostasis have shown that Atonal homolog 1 (Atoh1), a basic helix-loop-helix (bHLH) transcription factor, is essential for the intestinal goblet cell differentiation.
On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the “Ets” transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma.
Recent studies have demonstrated the relation of these factors, that is, Spdef functions downstream of Atoh1.
We could take the adventages of these findings for the study of otitis media because both middle ear and pulmonary epithelia belong to the same respiratory tract.
Atoh1 and SPDEF could be the therapeutic targets for otitis media associated with mucous cell metaplasia which is frequently considered “intractable” in the clinical settings.
American Psychological Association (APA)
Nakamura, Yoshihisa& Hamajima, Yuki& Komori, Masahiro& Yokota, Makoto& Suzuki, Motohiko& Lin, Jizhen. 2012. The Role of Atoh1 in Mucous Cell Metaplasia. International Journal of Otolaryngology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472362
Modern Language Association (MLA)
Nakamura, Yoshihisa…[et al.]. The Role of Atoh1 in Mucous Cell Metaplasia. International Journal of Otolaryngology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-472362
American Medical Association (AMA)
Nakamura, Yoshihisa& Hamajima, Yuki& Komori, Masahiro& Yokota, Makoto& Suzuki, Motohiko& Lin, Jizhen. The Role of Atoh1 in Mucous Cell Metaplasia. International Journal of Otolaryngology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-472362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472362