From Innate to Adaptive Immune Response in Muscular Dystrophies and Skeletal Muscle Regeneration : The Role of Lymphocytes
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Skeletal muscle is able to restore contractile functionality after injury thanks to its ability to regenerate.
Following muscle necrosis, debris is removed by macrophages, and muscle satellite cells (MuSCs), the muscle stem cells, are activated and subsequently proliferate, migrate, and form muscle fibers restoring muscle functionality.
In most muscle dystrophies (MDs), MuSCs fail to properly proliferate, differentiate, or replenish the stem cell compartment, leading to fibrotic deposition.
However, besides MuSCs, interstitial nonmyogenic cells and inflammatory cells also play a key role in orchestrating muscle repair.
A complete understanding of the complexity of these mechanisms should allow the design of interventions to attenuate MDs pathology without disrupting regenerative processes.
In this review we will focus on the contribution of immune cells in the onset and progression of MDs, with particular emphasis on Duchenne muscular dystrophy (DMD).
We will briefly summarize the current knowledge and recent advances made in our understanding of the involvement of different innate immune cells in MDs and will move on to critically evaluate the possible role of cell populations within the acquired immune response.
Revisiting previous observations in the light of recent evidence will likely change our current view of the onset and progression of the disease.
American Psychological Association (APA)
Madaro, Luca& Bouché, Marina. 2014. From Innate to Adaptive Immune Response in Muscular Dystrophies and Skeletal Muscle Regeneration : The Role of Lymphocytes. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-472373
Modern Language Association (MLA)
Madaro, Luca& Bouché, Marina. From Innate to Adaptive Immune Response in Muscular Dystrophies and Skeletal Muscle Regeneration : The Role of Lymphocytes. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-472373
American Medical Association (AMA)
Madaro, Luca& Bouché, Marina. From Innate to Adaptive Immune Response in Muscular Dystrophies and Skeletal Muscle Regeneration : The Role of Lymphocytes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-472373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472373